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In aging tissues, Tregs suppress immune responses by inducing senescence in effector T cells 139,140 , whereas MDSCs in tumors block T cell activation through molecules like IL-1RA 138,141

This type of nutrition therapy is also beneficial for those who are dehydrated due to illness, excessive drinking or other factors

In children with severe acute malnutrition, we have shown a major depletion of anaerobic microbes (intolerant to reactive oxidative species) 13 , consistent with the collapse of fecal butyrate in those who die 14